Lazertinib & Orforglipron Intermediates: Lifechem Pharma Manufacturer Guide to Key Building Blocks & CAS Numbers

The global pharmaceutical landscape in 2026 is witnessing surging commercial demand for advanced small-molecule therapeutics. In the European Union and United Kingdom, two high-impact active pharmaceutical ingredients (APIs) dominate procurement and R&D pipelines: Lazertinib (Lazcluze™)—the 3rd-generation EGFR tyrosine kinase inhibitor approved by the European Medicines Agency (EMA) for non-small cell lung cancer (NSCLC)—and Orforglipron (Foundayo™)—the first oral non-peptide GLP-1 receptor agonist authorized by the UK MHRA for chronic weight management and type 2 diabetes.

At Lifechem Pharma (lifechempharma.com), we specialize exclusively in the chemical synthesis and commercial manufacturing of high-purity API intermediates, Key Starting Materials (KSMs), and chiral building blocks. We supply pharmaceutical manufacturers, generic drug developers, and CDMOs across Europe and the UK with the exact, regulatory-compliant chemical intermediates required to synthesize Lazertinib (CAS: 1903008-80-9) and Orforglipron (CAS: 2212020-52-3).

This manufacturer’s guide provides technical directors, procurement heads, and process R&D chemists with complete technical specifications, synthesis pathways, CAS registries, and quality data for our in-house manufactured intermediates and chiral auxiliaries.

Lifechem Pharma’s Core Manufacturing Portfolio

As a dedicated API intermediate manufacturer, Lifechem Pharma produces the following 8 high-demand intermediates and chiral auxiliaries with guaranteed chromatographic purity, low residual solvents, and comprehensive analytical documentation:

Lazertinib Intermediate Chemistry & Lifechem Pharma’s Building Blocks

Lazertinib (CAS: 1903008-80-9) is synthesized via a convergent assembly connecting three critical chemical fragments: a pyrazole carbaldehyde core, a pyrimidine linker, and a substituted nitroaniline bearing the morpholine group.

Detailed Technical Specifications of Our Lazertinib Intermediates

• 3-Phenyl-1H-pyrazole-4-carbaldehyde (CAS: 26033-20-5): Molecular Formula: C10H8N2O | Molecular Weight: 172.18 g/mol. The essential pyrazole starting material providing the core pharmacophore for EGFR kinase domain selectivity. The C4-carbaldehyde group is specifically functionalized during downstream reductive amination to introduce the basic dimethylaminomethyl tail. Lifechem Quality Specification: Purity >= 99.0% (HPLC), off-white to light beige crystalline solid, moisture < 0.5%. Available in multi-kilogram to commercial metric-ton batches.
• 4-Fluoro-2-methoxy-5-nitroaniline (CAS: 1075705-01-9): Molecular Formula: C7H7FN2O3 | Molecular Weight: 186.14 g/mol. The primary fluorinated nitroaniline intermediate. The fluorine atom undergoes clean nucleophilic displacement with morpholine, cleanly establishing the substituted aniline tail while preventing regioisomeric side-reactions. Lifechem Quality Specification: Purity >= 98.5% (HPLC), melting point 140-144°C, single individual impurity < 0.5%.
• 4-Chloro-2-(methylthio)pyrimidine (CAS: 49844-90-8): Molecular Formula: C5H5ClN2S | Molecular Weight: 160.62 g/mol. The heterocyclic pyrimidine bridge linking the pyrazole and aniline fragments. Following C4 substitution with the pyrazole nitrogen, the thiomethyl (-SCH3) group is oxidized to a reactive sulfone group for subsequent C2 aromatic substitution. Lifechem Quality Specification: Purity >= 98.0% (GC/HPLC), low water content, packaged under inert nitrogen atmosphere.

Controlling Lazertinib Impurities Through High-Purity Intermediates

Under ICH Q3A(R2) and ICH M7 guidelines, controlling process-related impurities at the finished API stage begins with strict impurity limits in upstream raw materials:

By sourcing starting materials directly from Lifechem Pharma, formulation manufacturers ensure their crude API batches consistently stay below the 0.10% ICH reporting threshold for individual impurities.

Orforglipron Intermediate Chemistry & Lifechem Pharma’s Chiral Auxiliaries

Orforglipron (CAS: 2212020-52-3 / Hemicalcium Salt CAS: 2415797-61-2) is a non-peptide small-molecule GLP-1 receptor agonist. Its multi-step convergent manufacturing route requires high stereoselectivity (ee > 99.5%), which is governed by Evans chiral auxiliaries and functionalized heterocyclic building blocks manufactured at Lifechem Pharma.

Detailed Technical Specifications of Our Orforglipron Intermediates & Chiral Auxiliaries

• 5-Bromo-1H-indole-2-carboxylic acid (CAS: 7254-19-5): Molecular Formula: C9H6BrNO2 | Molecular Weight: 240.05 g/mol. The primary indole heterocyclic backbone. The C5-bromo position serves as the active handle for transition-metal catalyzed coupling to assemble the tetrahydropyranyl-indole scaffold. Lifechem Quality Specification: Purity >= 99.0% (HPLC), off-white to beige crystalline solid, loss on drying < 0.5%.
• (R)-4-Methyl-1,3,2-dioxathiolane 2,2-dioxide (CAS: 1006381-03-8): Molecular Formula: C3H6O4S | Molecular Weight: 138.14 g/mol. A stereospecific chiral cyclic sulfate electrophile used for the clean, racemization-free introduction of chiral methyl-branched side chains with complete inversion of configuration. Lifechem Quality Specification: Purity >= 98.5% (GC), chiral optical purity ee > 99.0%, low moisture.
• (R)-4-Benzyl-2-oxazolidinone (CAS: 102029-44-7): Molecular Formula: C10H11NO2 | Molecular Weight: 177.20 g/mol. Industry-standard Evans chiral auxiliary. Utilized in asymmetric 1,4-conjugate additions and chiral alkylation steps to install single enantiomeric stereocenters with high stereoselection. Lifechem Quality Specification: Purity >= 99.0% (HPLC), specific optical rotation [a]D20 = +59° to +63° (c=1, ethanol), white crystalline powder.
• (R)-(+)-4-Phenyl-2-oxazolidinone (CAS: 90319-52-1) & (S)-(+)-4-Phenyl-2-oxazolidinone (CAS: 99395-88-7): Molecular Formula: C9H9NO2 | Molecular Weight: 163.17 g/mol. Complementary Evans auxiliaries providing steric modulation for chiral induction and resolution in custom Orforglipron scale-up pathways. Lifechem Quality Specification: Purity >= 99.0% (HPLC), enantiomeric excess ee > 99.5%, heavy metals < 10 ppm.

Why Choose Lifechem Pharma as Your Intermediate Supply Partner?

European and UK pharmaceutical companies require dependable, audit-ready chemical manufacturers capable of delivering batch-to-batch consistency. Lifechem Pharma (lifechempharma.com) provides:

• 100% Dedicated Intermediate Manufacturer: We focus solely on chemical intermediates, KSMs, and chiral auxiliaries.
• Analytical Transparency: Every batch includes Certificate of Analysis (CoA), 1H/13C NMR, HPLC/GC chromatograms, and MSDS.
• Chiral Integrity: Rigorous chiral HPLC and polarimetric verification (ee > 99.0%).
• Flexible Supply Scale: From 1 kg pilot R&D lots to multi-ton commercial manufacturing capacity.
• Regulatory Documentation: Full support with Route of Synthesis (ROS) and REACH compliance.
• Fast European Export: Direct temperature-controlled air/sea shipping to UK and EU ports (Germany, Switzerland, Ireland, France, Italy).