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4-Chloro-2-(Methylthio)Pyrimidine

4-Chloro-2-(Methylthio)Pyrimidine | 49844-90-8 | Lazertinib

4-Chloro-2-(Methylthio)Pyrimidine is a highly versatile pyrimidine-based pharmaceutical intermediate that serves as a critical building block in the synthesis of Lazertinib (YH25448), a third-generation EGFR tyrosine kinase inhibitor approved for the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). LifeChem Pharma is a trusted bulk manufacturer and supplier of 4-Chloro-2-(Methylthio)Pyrimidine, offering pharmaceutical-grade material with consistently high purity of ≥98%.

CAS No :

49844-90-8

Formula :

C₅H₅ClN₂S

Weight :

160.62 g/mol

USE API :

Lazertinib

Category:

Product Specification

  • Appearance & Physical State – Colorless to pale yellow liquid
  • Assay (HPLC) – ≥ 98%
  • Impurity Profile – Controlled as per pharmaceutical standards (ICH Q3A)
  • Moisture Content – ≤ 0.5%
  • Solubility – Soluble in DMSO, acetonitrile, and common organic solvents
  • Storage Condition – Store in cool, dry, well-ventilated area away from moisture and heat
  • Packaging – 1 L / 5 L / 25 L / 200 L HDPE jerrycan or drum

Safety Information As Per GHS

  • Irritating to skin, eyes, and respiratory tract upon contact
  • Avoid inhalation of dust or vapors during handling
  • Use appropriate personal protective equipment including gloves, goggles, and mask
  • Keep container tightly sealed away from moisture and heat sources
  • Refer to the Safety Data Sheet (SDS) for complete hazard classification and first-aid measures
4-Chloro-2-(Methylthio)Pyrimidine (CAS No. 1996-07-2) is a pyrimidine derivative with the molecular formula C₅H₅ClN₂S and a molecular weight of 160.62 g/mol. The structure features a six-membered pyrimidine ring with a reactive chloro (–Cl) group at the 4-position and a methylthio (–SCH₃) group at the 2-position. This dual functionality makes 4-Chloro-2-(Methylthio)Pyrimidine an exceptionally useful electrophilic building block, enabling selective nucleophilic aromatic substitution reactions at both positions under controlled reaction conditions

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