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4-Fluoro-2-methoxy-5-nitroaniline

4-Fluoro-2-Methoxy-5-Nitroaniline Manufacturer | 1075705-01-9

4-Fluoro-2-Methoxy-5-Nitroaniline is a highly valuable fluorinated aniline intermediate widely used in pharmaceutical synthesis, particularly as a key building block in the manufacture of Lazertinib (YH25448), a third-generation EGFR tyrosine kinase inhibitor approved for the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). LifeChem Pharma is a trusted bulk manufacturer and supplier of 4-Fluoro-2-Methoxy-5-Nitroaniline, offering pharmaceutical-grade material with consistently high purity of ≥98%.

CAS NO :

1075705-01-9

Formula :

C₇H₇FN₂O₃

Weight :

186.14 g/mol

USE API :

Lazertinib

Category:

Product Specification

  • Appearance & Physical State – Yellow to orange crystalline solid
  • Assay (HPLC) – ≥ 98%
  • Impurity Profile – Controlled as per pharmaceutical standards (ICH Q3A)
  • Moisture Content – ≤ 0.5%
  • Solubility – Soluble in DMSO, ethanol, and common organic solvents
  • Storage Condition – Store in cool, dry, well-ventilated area away from direct light and moisture
  • Packaging – 1 kg / 5 kg / 25 kg HDPE container or fiber drum

Safety Information As Per GHS

  • May cause skin and eye irritation upon direct contact
  • Avoid inhalation of dust or vapors during handling
  • Use appropriate personal protective equipment including gloves, goggles, and protective clothing
  • Keep container tightly sealed when not in use
  • Refer to the Safety Data Sheet (SDS) for complete hazard classification and first-aid measures
4-Fluoro-2-Methoxy-5-Nitroaniline (CAS No. 1075705-01-9) is a substituted aniline compound with the molecular formula C₇H₇FN₂O₃ and a molecular weight of 186.14 g/mol. The structure features a benzene ring bearing a primary amine (–NH₂) at position 1, a methoxy (–OCH₃) group at position 2, a fluoro (–F) substituent at position 4, and a nitro (–NO₂) group at position 5. This unique combination of electron-withdrawing and electron-donating substituents makes 4-Fluoro-2-Methoxy-5-Nitroaniline an exceptionally reactive and selective intermediate for multi-step pharmaceutical synthesis.

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