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4-Bromo-3-nitro anisole

4-Bromo-3-nitro anisole

Synonym : 1-Bromo-4-methoxy-2-nitrobenzene, 4-Bromo-3-nitroanisole, 4-Bromo-3-nitro-1-methoxybenzene, 4-Bromo-3-nitrophenyl methyl ether, 3-Nitro-4-bromoanisole

  • General Information : 4-Bromo-3-nitro anisole
  • Molecular Weight: 246.03 g/mol
  • Density: 1.7 – 1.8 g/cm³
  • Physical state: Solid
  • Boiling point: 285–290°C
  • Condition to Avoid: Heat and flames
  • Used For: Pharmaceutical Intermediates, Organic Synthesis, Agrochemical Industry, Research & Development
Cas No : :

5344-78-5

European Community (EC) Number : :

EINECS/EC

Mol Formula : :

C₇H₆BrNO₃

Purity by GC: Typically: :

≥ 98%

Category:

Product Specification

  • Appearance: Yellow to light brown crystalline powder
  • Purity by GC: ≥ 98%
  • IUPAC Name : 1-Bromo-4-methoxy-2-nitrobenzene
  • Storage Condition: cool, dry place and moisture, heat, and light
  • Transport Condition: ambient temperature, moisture-proof and sealed packaging
  • Pack size: 25g, 100g, 500g, 1kg, 5kg, 25kg, or as per customer requirements
  • Production Capacity: Several metric tons per year
  • Packing Material: Primary packing material: Double-layered polyethylene (PE) bags or glass bottles for smaller quantities
  • Secondary packing material: Fiber drums, HDPE drums, or cartons for bulk shipping
  • For Export: REACH (EU), GHS, and other international regulations

Safety Information As Per GHS

  • GHS Classification includes various hazard categories.
  • The product\'s P-Codes stress prevention methods.
  • Keep P403+P233 and P405 in a well-ventilated, locked area.
  • Proper disposal of contents or containers per regulations.
  • The product can irritate the respiratory, skin, and eyes. Handle carefully; avoid environmental release.

4-Bromo-3-nitro anisole Has Several Applications, Including:

Organic synthesis:

4-Bromo-3-nitroanisole is a crucial intermediate in organic synthesis, used for coupling reactions, synthesis of amino derivatives, and halogen substitution reactions. It serves as a precursor in Suzuki-Miyaura, Heck, and Buchwald–Hartwig cross-coupling reactions, providing access to key aniline derivatives in dye and pharmaceutical industries.

Pharmaceuticals:

4-Bromo-3-nitroanisole is a crucial intermediate in drug development and synthesis, used in API synthesis for antibacterial, antiviral, and anticancer drugs, heterocyclic compound synthesis for pharmaceutical compounds, and in drug development for novel prodrugs and bioactive molecules.

Research:

Medicinal Chemistry focuses on developing new drug leads, agrochemicals synthesize pesticides and herbicides, and material science serves as precursors for functional materials like dyes and pigments.

Conclusion:

4-Bromo-3-nitroanisole is a highly versatile compound in organic synthesis, pharmaceuticals, and research. Its reactive bromo and nitro groups make it an ideal intermediate for producing a wide range of complex molecules. Given its importance, it is widely utilized in drug discovery, fine chemicals, and advanced material sciences.

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