2-4 dichloropyrimidine | 2,4-dichloro-pyrimidine | 2-Chloropyrimidin-4-yl chloride | NSC 37531 | 2,4-Dichlorpyrimidin | Pyrimidine, 2,4-dichloro- | 2,4-Dichloropyrimidi | NSC 20212 | NSC 49119
2-4 dichloropyrimidine | 2,4-Dichloropyrimidine is a human skin sensitizer. It goes through a highly efficient one-pot, regioselective , double Suzuki coupling reaction that yields diarylated pyrimidines. [2-4 dichloropyrimidine]
Suzuki coupling reaction is frequently used to prepare of a wide range of substituted Pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated.
A thorough examination of reaction conditions as well as the application of microwave radiation resulted in a highly effective and simple synthetic procedure offering C4-substituted pyrimidines with good yields to exceptional levels.
Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings. [2-4 dichloropyrimidine]
2-4 dichloropyrimidine manufacturers in india
2,4-Dichloropyrimidine can be used as a human skin sensitizer. It is subject to a one-pot, regioselective Suzuki coupling reaction that yields diarylated Pyrimidines.
2,4-Dichloropyrimidine was used to synthesize medicinally important 4-aryl-5 pyrimidinyl imidazoles.
Use of sodium sulfonate and tetrabutylammonium bromide as temporary nucleophiles allows for highly regioselective 2,4-dichloropyrimidine amination by weakly nucleophilic amines. This protocol was simple and environmentally friendly and can be applied to many amines as well as activated N-heteroaromatic substrats.
It is revealed that a highly efficient and selective method has been developed for the SNAr animation (2,4-dichloropyrimidine) with oxazolidin-2,one and related weakly Nucleophilic amines.
This was done using sodium sulfinate as a catalyst and tetrabutylammonium bromide as a reactant. This strategy allows for the synthesis and modification of many aminopyrimidines in an efficient and chemoselective way. This strategy was used successfully to amination activated N-heteroaromatic substrates.
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- Appearance & Physical State – White crystalline powder
- Molecular weight – 148.97800
- Boiling point – 101 °C (23 mmHg), 100 °C (19 mmHg)
- Flash Point – 104.3±5.4 °C (predict)
- Density – 1.493 g/cm3 (predict)
- Storage Condition – -20ºC
- Stability – Stable at room temperature in closed containers under normal storage and handling conditions.
Safety Information As Per GHS
Hazard - 8 corrosive [2-4 dichloropyrimidine]
Hazard Statement(s) as per GHS
- H315: Causes skin irritation.
- H319: Causes serious eye irritation
- H335: May cause respiratory irritation