2-4 dichloropyrimidine

Lifechem Products

2-4 dichloropyrimidine

CAS No :	3934-20-1
EC Number :	223-508-6
Formula :	C4H2Cl2N2

Categories: Hetrocyclics Compound, Well Built Product

Product Specification

Appearance & Physical State – White crystalline powder
Molecular weight – 148.97800
Boiling point – 101 °C (23 mmHg), 100 °C (19 mmHg)
Flash Point – 104.3±5.4 °C (predict)
Density – 1.493 g/cm3 (predict)
Storage Condition – -20ºC
Stability – Stable at room temperature in closed containers under normal storage and handling conditions.

Safety Information As Per GHS

Hazard - 8 corrosive [2-4 dichloropyrimidine]

Hazard Statement(s) as per GHS

H315: Causes skin irritation.
H319: Causes serious eye irritation
H335: May cause respiratory irritation

2-4 dichloropyrimidine | 2,4-Dichloropyrimidine is a human skin sensitizer. It goes through a highly efficient one-pot, regioselective , double Suzuki coupling reaction that yields diarylated pyrimidines. [2-4 dichloropyrimidine] Suzuki coupling reaction is frequently used to prepare of a wide range of substituted Pyrimidines. In this study, the Suzuki coupling of 2,4-dichloropyrimidines with aryl and heteroaryl boronic acids was investigated. A thorough examination of reaction conditions as well as the application of microwave radiation resulted in a highly effective and simple synthetic procedure offering C4-substituted pyrimidines with good yields to exceptional levels. Short reaction time (15 min) and extremely low catalyst loading (0.5 mol%) are the main advantages of our tetrakis(triphenylphosphine)palladium(0) catalyzed microwave-assisted procedure, which could be used for quick and low-cost regioselective preparation of substituted pyrimidine rings. [2-4 dichloropyrimidine]

2-4 dichloropyrimidine manufacturers in india

2,4-Dichloropyrimidine can be used as a human skin sensitizer. It is subject to a one-pot, regioselective Suzuki coupling reaction that yields diarylated Pyrimidines. 2,4-Dichloropyrimidine was used to synthesize medicinally important 4-aryl-5 pyrimidinyl imidazoles. Use of sodium sulfonate and tetrabutylammonium bromide as temporary nucleophiles allows for highly regioselective 2,4-dichloropyrimidine amination by weakly nucleophilic amines. This protocol was simple and environmentally friendly and can be applied to many amines as well as activated N-heteroaromatic substrats. It is revealed that a highly efficient and selective method has been developed for the SNAr animation (2,4-dichloropyrimidine) with oxazolidin-2,one and related weakly Nucleophilic amines. This was done using sodium sulfinate as a catalyst and tetrabutylammonium bromide as a reactant. This strategy allows for the synthesis and modification of many aminopyrimidines in an efficient and chemoselective way. This strategy was used successfully to amination activated N-heteroaromatic substrates.