Propane phosphonic acid anhydride (T3P), 50% solution
- CAS No.
- 68957-94-8
- Molecular formula
- C9H21O6P3
- Molecular weight
- 318.18 g/mol
- Purity
- 50% solution
AppearanceClear colourless to pale yellow solution
Price, specification and samples on request · reply within one working day
Made in our own plantsPanoli GIDC, Ankleshwar
Tested in our QC labHPLC · GC · KF and more
COA & SDSShared with every quotation
Grams to multi-tonnesSamples to commercial supply
Overview
Propane phosphonic acid anhydride (propylphosphonic anhydride, T3P) is a cyclic trimer of propylphosphonic acid anhydride and one of the most widely used coupling reagents for amide and peptide bond formation. It gives high yields with very low epimerisation, and its by-products are water-soluble phosphonic acids that are removed by a simple aqueous wash.
Besides amide coupling, T3P is used for esterification, macrolactamisation and dehydration reactions, for example to convert amides and aldoximes into nitriles. It is non-toxic and non-sensitising compared with many classic coupling agents, which makes it well suited to scale-up and API manufacturing.
We supply T3P as a 50% solution in ethyl acetate, MDC (dichloromethane), DMF, THF or acetonitrile, so the solvent can match your process. Each lot is tested before release.
Applications
- Amide and peptide bond formation with low epimerisation
- Esterification and macrolactamisation
- Dehydration of amides and aldoximes to nitriles
- Coupling step in API manufacturing with easy aqueous work-up
Technical specifications
| Concentration | 50% solution |
|---|---|
| Solvent options | Ethyl acetate / MDC / DMF / THF / Acetonitrile |
| Molecular weight (T3P) | 318.18 g/mol |
Packaging & storage
As per customer requirement
Store tightly closed in a cool, dry, well-ventilated place, protected from moisture and away from heat and ignition sources
Safety information
- H314: Causes severe skin burns and eye damage.
- H290: May be corrosive to metals.
- Solutions in ethyl acetate, THF and acetonitrile are flammable
- Reacts with water: keep dry
- Wear protective gloves, protective clothing and eye/face protection
- Refer to SDS for complete safety and handling information
Full details are in the Safety Data Sheet, sent with every quotation.