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Chloromethyl Methyl Ether

Chloromethyl methyl ether | methoxy methylene chloride | Ether, chloromethyl methyl (6CI,8CI) | 1-Chloro-1-methoxy methane | NSC 21208 | MOMCl | Monochlorodimethyl ether | NSC 93873 | Monochloromethyl methyl ether | Monochlorodimethylene ether | Chloromethoxymethane | Methane, chloromethoxy- | chloro(methyloxy)methane | Methoxymethyl chloride | chloro-methyl methyl ether | methyl chloromethyl ether | Ether,chloromethyl methyl | Methane,chloromethoxy | methoxychloromethane | Chlorodimethyl ether

Chloromethyl methyl ether manufacturers in india

The compound chloromethyl methyl ether is a compound that has the formula CH3OCH2Cl. It is a chloroalkyl ether. It is used to alkylate and as an industrial solvent for the manufacture of detergent dodecyl benzyl chloride, water repellents, and ion exchange resins. It is often used in organic synthesis to introduce the methoxymethyl (MOM), protecting group. It can also be used as a chloromethylation agent for some versions of Blanc chloromethylation.

It is possible to make chloromethyl methyl ether in situ by using dimethoxyethane with acetyl chloride. This can be done either as a solution or straight in an inert solvent such as toluene. This combination yields a high-purity solution of chloromethyl methyl ether in methylacetate (>95%) that can be used in many applications.

You can prepare pure material using a very similar process, which uses a high-boiling, acyl chloride. This method produces >93% pure material after simple distillation with dimethoxymethane being the only contaminant. The classical method described in Organic Syntheses, which uses formaldehyde and methanol, yields material that is contaminated with significant amounts of bis(chloromethyl ether) and requires fractional distillation.

It has been determined how long it takes to remove residual chloromethyl methyl ether from standard aqueous quench solutions (ammonium chloride solution, water and sodium carbonate solution). After vigorous stirring for 15 minutes with the quench solution, all solutions of chloromethyl methyl ether in toluene/ethyl acetate were destroyed (to within the detection limit).

CMME is a well-known human carcinogen. Chronic exposure can lead to an increase in the risk of developing small-cell carcinoma and other respiratory cancers. Despite not having an established exposure limit, it is one of the 13 chemicals regulated under the Occupational Safety and Health Administration.

It is classified in the United States as an extremely dangerous substance according to Section 302 U.S.A. 42 U.S.C. It is subject to stringent reporting requirements by any facility that produces, stores, or uses it in large quantities. It is included in Schedule 1 Part 1 of Canada’s Prohibition of Certain Toxic Substances Regulations.

what is chloromethylation

Mechanism. The reaction takes place in an acidic environment with a ZnCl2 catalyst. These circumstances protonate the carbonyl of formaldehyde, making it much more electrophilic. The aromatic pi-electrons next attack the aldehyde, followed by aromatic ring rearomatization.


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Product Specification

  • Appearance & Physical State – Achromatism to Pale yellow liquid
  • Molecular weight – 80.51350
  • Boiling point – 55-59ºC
  • Flash Point – 15ºC
  • Density – 1.06
  • Vapor Pressure – 3.55 psi ( 20 °C)
  • Storage Condition – 0-6ºC
  • Water Solubility- decomposes

Safety Information As Per GHS

  • Hazard - 6 corrosive