N-Hydroxyphthalimide
NHPI
N-Hydroxyphthalimide (NHPI) is an N-hydroxy imide widely used in peptide chemistry and organic synthesis. It reacts with carboxylic acids to give NHPI active esters, which couple cleanly with amines to form amide bonds.
- CAS No.
- 524-38-9
- Molecular formula
- C8H5NO3
- Molecular weight
- 163.13 g/mol
- Purity
- On request
AppearanceWhite to off-white crystalline powder
Price, specification and samples on request · reply within one working day
Made in our own plantsPanoli GIDC, Ankleshwar
Tested in our QC labHPLC · GC · KF and more
COA & SDSShared with every quotation
Grams to multi-tonnesSamples to commercial supply
Overview
NHPI is also a well-known organocatalyst for aerobic oxidations: together with cobalt or other co-catalysts it generates the phthalimide N-oxyl (PINO) radical, which oxidises hydrocarbons, alcohols and other substrates with air or oxygen. NHPI esters are used as redox-active esters in modern decarboxylative cross-coupling reactions.
Our N-Hydroxyphthalimide is produced under strict quality control to ensure high chemical purity and consistent batch-to-batch quality. Each lot is tested before release.
Applications
- Coupling additive and active ester formation in peptide synthesis
- Organocatalyst for aerobic oxidation reactions
- Redox-active NHPI esters for decarboxylative cross-coupling
- Intermediate for pharmaceuticals and fine chemicals
Technical specifications
| Molecular weight | 163.13 g/mol |
|---|---|
| Melting point | approx. 233 °C (decomposes) |
| IUPAC name | 2-Hydroxyisoindole-1,3-dione |
Packaging & storage
1 kg / 5 kg / 25 kg HDPE or fiber drum
Store in cool, dry place in tightly closed container
Safety information
- H315: Causes skin irritation.
- H319: Causes serious eye irritation.
- H335: May cause respiratory irritation.
- Use protective gloves and eye protection
- Refer to SDS for complete safety and handling information
Full details are in the Safety Data Sheet, sent with every quotation.