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4-Toluenesulfonylhydrazide / Tosyl hydrazide

4-Toluenesulfonylhydrazide / Tosyl hydrazide

Synonym : p-Toluenesulfonhydrazide, p-Toluenesulfonic acid hydrazide, p-Toluenesulfonyl hydrazide
Tosylhydrazide, 4-Methylbenzenesulfonohydrazide, p-Methylbenzenesulfonohydrazide, Toluene-4-sulfonyl hydrazide

  • General Information : 4-Toluenesulfonylhydrazide
  • Molecular Weight: 214.28 g/mol
  • Density: 1.23 g/cm³
  • Physical state: solid
  • Boiling point: 300°C (572°F).
  • Condition to Avoid: Moisture, Excessive heat
  • Used For: organic synthesis and pharmaceutical research, synthesis of hydrazones and hydrazides
Cas No : :

1576-35-8

European Community (EC) Number :

204-727-9

Mol Formula :

C7H10N2O2S

Purity by GC: Typically :

≥ 98%

Category:

Product Specification

  • Appearance: White to off-white crystalline powder
  • Purity by GC: ≥98%
  • IUPAC Name : 4-Methylbenzenesulfonohydrazide
  • Storage Condition: cool, dry place
  • Transport Condition: ambient temperature, moisture-proof, and sealed packaging
  • Pack size: 25g, 100g, 500g, 1kg, 5kg, 25kg or as per customer requirements
  • Production Capacity: Varies by manufacturer, but generally several metric tons per year
  • Packing Material: Primary packing material: Double-layered polyethylene (PE) bags or glass bottles (for smaller quantities)
  • Secondary packing material: Fiber drums, HDPE drums, or cartons for bulk shipping
  • For Export: REACH (EU), GHS, and other international regulations

Safety Information As Per GHS

  • GHS Classification divides hazards into several toxicity categories.
  • If swallowed, call a poison center or doctor if unwell.
  • The product can irritate the eyes, skin, and lungs. Wear safety goggles and handle them carefully.
  • The product\\\'s P-Codes highlight prevention measures against dust, fumes, and sprays.

Toluenesulfonylhydrazide Has Several Applications, Including:

Organic synthesis:

4-Toluenesulfonylhydrazide is a versatile reagent in organic synthesis due to its strong nucleophilic and reducing properties. Key applications include hydrazone synthesis, reduction reactions, heterocyclic compound synthesis, and radical reactions. It reacts with carbonyl compounds to form intermediates, aids in chemical transformations, and generates free radicals for radical-mediated transformations.

Pharmaceuticals:

4-Toluenesulfonylhydrazide, a drug intermediate, is used in the synthesis of pharmaceutical intermediates and active ingredients, with promising biological activities in antimicrobial and cancer research.

Research:

Analytical chemistry uses spectrophotometric and chromatographic analyses as derivatization reagents. Material science modifies polymer structures and develops new materials. Agricultural chemistry investigates agrochemicals like pesticides and herbicides.

Conclusion:

4-Toluenesulfonylhydrazide is a crucial reagent in organic synthesis, pharmaceuticals, and research due to its ability to form hydrazones, participate in reduction reactions, and serve as a drug development intermediate.

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