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2, 2, 6, 6 Tetramethylpiperidine

2,2,6,6 Tetramethylpiperidine

Synonym(s): 2,2,6,6 tetramethylpiperidide, 2,2,6,6-tetramethylpiperidine, Norpempidine, TEMP, TMPH

2,2,6,6 Tetramethylpiperidine, often known as TMP, HTMP, or TMPH, is a chemical molecule in the amine class. It appears to be a white liquid with a “fishy” amine-like odor. This amine is known in chemistry as a hindered base. Although TMP is not widely used, its derivatives are a key component of hindered amine light stabilizers.

TMP is the precursor of lithium tetramethylpiperidide, an even stronger base, as well as the radical species TEMPO. Another non-nucleophilic base is N,N-diisopropylethylamine. At 25 °C, its aqueous pKaH (conjugate acid dissociation constant, a measure of basicity) is 11.07, while its pKa (acid dissociation constant, a measure of acidity) is around 37.

There have been several reports on various TMP synthesis methods. One approach begins with a conjugate addition reaction of ammonia and phorone. The intermediate triacetone amine is subsequently reduced by a Wolff-Kishner reaction.


CAS No :



Product Specification

  • Chemical formula : C9H19N
  • Molar mass : 141.254 g/mol
  • Appearance : Clear liquid
  • Density : 0.83 g/mL
  • Melting point : −59 °C (−74 °F; 214 K)
  • Boiling point : 152 °C (306 °F; 425 K)

Safety Information As Per GHS


GHS-pictogram-skull GHS-pictogram-flamme GHS-pictogram-exclam GHS-pictogram-acid

Signal Word : Danger

Hazard statements

H226, H301, H302, H314, H315, H319, H332, H335

Precautionary statements

P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501