N-methoxy-N-methyl Acetamide

N-Methoxy-N-MethylAcetamideN-Methylacetamide (NMA) continues to draw both experimental and theoretical interest since it is believed to be simple, but the real-world model system for the peptide group of proteins [94-106]. The principal issue is the conformation of the molecular.

In reality, the position of the two torsional angles of the backbone and the energy of the respective rotations are crucial to stabilizing peptide as well as protein structure. NMA is trans- and Cis-conformers that are both close to each other in terms of energy, which is why advanced theoretical approaches are required to provide a reliable description of the conformational properties.

When in the gas state, the trans conformer dominates [102], whereas NMR measurements in aqueous solutions [100,103show the cis conformation to be the absolute minimum. In proteins and peptides, each conformer has been detected however, the trans configuration is more widespread (it is preferred 103 times more than the cis form).

Solvation may be among the main factors that cause the differences in stability between the trans and cis conformers of the peptides. Therefore it’s very beneficial to conduct research considering solvent-related influences.