Lifechem Products
Propanephosphonic acid anhydride (50% solution in ethyl acetate)
50 solution in ethyl acetate – Propylphosphonic anhydride is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low-toxic coupling agent used in peptide synthesis. it also acts as a promoter and water scavenger in the Friedländer annulation reaction.
CAS No : | 68957-94-8 |
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EC Number : | 422-210-5 |
Product Specification
Propylphosphonic anhydride can be used:
- As an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2).
- In the synthesis of substituted benzofurans as potent DNA gyraseB inhibitors of Mycobacterium tuberculosis.
- As a catalyst in the synthesis of benzothiazoles, benzoxazoles, and benzimidazoles under microwave irradiation.
- As a catalyst in the conversion of ketoximes to amides and aldoximes to nitriles via Beckmann rearrangement.
- As a reagent in the one-pot conversion of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles.
Safety Information As Per GHS
- Hazard Classifications Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
- Signal Word Danger
- Target Organs Respiratory system
- Flash Point(F) 24.8 °F - closed cup
- Flash Point(C) -4 °C - closed cup
- Storage Class Code 3 - Flammable liquids
- WGK WGK 1
It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols, and C-C coupling reactions.it delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products, giving high purity and yield of the product.
Propylphosphonic anhydride may be used in the following studies:
- As a coupling agent for the synthesis of bipyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
- Microwave-assisted Fischer indolization of arylhydrazines.
- As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
- One-pot synthesis of coumarins.
- Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
- One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
- Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.
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