Propanephosphonic acid anhydride (50% solution in ethyl acetate)

Lifechem Products

Propanephosphonic acid anhydride (50% solution in ethyl acetate)

50 solution in ethyl acetate – Propylphosphonic anhydride is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low-toxic coupling agent used in peptide synthesis. it also acts as a promoter and water scavenger in the Friedländer annulation reaction.

CAS No :	68957-94-8
EC Number :	422-210-5

Category: Peptide Synthesis

Product Specification

Propylphosphonic anhydride can be used:

As an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2).
In the synthesis of substituted benzofurans as potent DNA gyraseB inhibitors of Mycobacterium tuberculosis.
As a catalyst in the synthesis of benzothiazoles, benzoxazoles, and benzimidazoles under microwave irradiation.
As a catalyst in the conversion of ketoximes to amides and aldoximes to nitriles via Beckmann rearrangement.
As a reagent in the one-pot conversion of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles.

Safety Information As Per GHS

Hazard Classifications Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
Signal Word Danger
Target Organs Respiratory system
Flash Point(F) 24.8 °F - closed cup
Flash Point(C) -4 °C - closed cup
Storage Class Code 3 - Flammable liquids
WGK WGK 1

It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols, and C-C coupling reactions.it delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products, giving high purity and yield of the product.

Propylphosphonic anhydride may be used in the following studies:

As a coupling agent for the synthesis of bipyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
Microwave-assisted Fischer indolization of arylhydrazines.
As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
One-pot synthesis of coumarins.
Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.