Lifechem Products

Propanephosphonic acid anhydride (50% solution in ethyl acetate)

50 solution in ethyl acetate – Propylphosphonic anhydride is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low-toxic coupling agent used in peptide synthesis. it also acts as a promoter and water scavenger in the Friedländer annulation reaction.

It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols, and C-C coupling reactions.

it delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products, giving high purity and yield of the product.

Propylphosphonic anhydride may be used in the following studies:

  • As a coupling agent for the synthesis of bipyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
  • Microwave-assisted Fischer indolization of arylhydrazines.
  • As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
  • One-pot synthesis of coumarins.
  • Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
  • One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
  • Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.
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Product Specification

Propylphosphonic anhydride can be used:

  • As an acid-amine coupling reagent for the synthesis of 3-(trifluoromethyl)-1H-pyrazole-5-carboxamides which are potent activators of pyruvate kinase M2 (PKM2).
  • In the synthesis of substituted benzofurans as potent DNA gyraseB inhibitors of Mycobacterium tuberculosis.
  • As a catalyst in the synthesis of benzothiazoles, benzoxazoles, and benzimidazoles under microwave irradiation.
  • As a catalyst in the conversion of ketoximes to amides and aldoximes to nitriles via Beckmann rearrangement.
  • As a reagent in the one-pot conversion of aromatic, heteroaromatic, and aliphatic aldehydes to nitriles.

Safety Information As Per GHS

  • Hazard Classifications Eye Dam. 1 - Flam. Liq. 2 - Met. Corr. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
  • Signal Word Danger
  • Target Organs  Respiratory system
  • Flash Point(F)  24.8 °F - closed cup
  • Flash Point(C) -4 °C - closed cup
  • Storage Class Code  3 - Flammable liquids
  • WGK  WGK 1