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Lifechem Products

4-hydroxy Benzyl Alcohol

Benzenemethanol, 4-hydroxy, 4-hydroxymethyl-phenol, 4-hydroxybenzyl-alcohol, 4-Hydroxybenzyl alcohol, PARA-ALCOHOLPHENOL, RARECHEM AL BD 0098, FEMA 3987, p-Methylolphenol, p-Hydroxybenzyl, Gastrodigenin, 4-METHYLOLPHENOL

4-Hydroxy Benzyl Alcohol

The 4-hydroxybenzyl alcohol (HBA) is a phenolic substance that is found inside Gastrodia elata. It acts used as an antioxidant as well as an anti-asthmatic.

4-Hydroxybenzyl Alcohol can be utilized as a precursor to the synthesizing of:

HBA-integrated copolyoxalate (HPOX) nanoparticles that could be a drug delivery systems.

Poly(4-hydroxybenzyl alcohol) via enzyme catalyzed reactions.

4-Hydroxybenzyl imidazole derivatives.

4-hydroxybenzoic acid, p-hydroxybenzyl alcohol, and 4-hydroxy-benzaldehyde are the main chemical constituents obtained from the vanilla beans. Numerous variables, including the conditions of growth such as species and soil composition, as well as maturation of the fruit, and processing impact the chemical constituents of vanilla beans.

4-hydroxybenzyl Alcohol is the product of cleavage that is produced in the biosynthesis process of the Thiazole moiety from tyrosine in the biosynthesis pathway of thiamine. It is an alcohol derivative of benzyl alcohol which is utilized to treat local pain and to alleviate pain that is caused by Lidocaine injections. It is also used to make other benzyl compounds as an aid to pharmaceuticals, and in flavoring and perfumery.

Benzyl Alcohol is an aromatic alcohol that is utilized in a range of cosmetic formulations as fragrance ingredient, solvent, preservative and viscosity decreasing agent. Benzyl Alcohol is metabolized to Benzoic Acid, which reacts with glycine before being eliminated as hippuric acid within our bodies.

Daily intakes that are acceptable were determined through the World Health Organization at 5 mg/kg for Benzyl Alcohol. There are no adverse reactions to benzyl alcohol were observed in the study of chronic exposure in animals that included mice and rats.

The effects from Benzyl Alcohol in research on chronic exposure in animals are restricted to decreased intake of feed and decreased growth. There were some differences in a study of reproductive toxicity with mice, however these were restricted to lower maternal body weights as well as lower average litter sizes.

A different study also found that the weight of the fetus was reduced when compared with controls, however the third study did not show difference between the groups treated with benzyl Alcohol and those without. Benzyl Alcohol has been associated with an increase in malformations and resorptions in Hamsters. However, there are no developmental or reproductive toxicological findings from studies conducted using rats and mice.

Genotoxicity tests for benzyl Alcohol are generally negative, however there were some tests which were positive. Studies on carcinogenicity, however, were not positive. Research suggests that benzyl alcohol may cause nonimmunologic urticaria due to contact and immediate contact reactions. They are identified by wheals, erythema and pruritis.

5% benzyl alcohol can elicit a reaction. Benzyl Alcohol does not cause sensitization below 10 percent. Benzyl Alcohol could be used in a safe manner at concentrations as high as 5 percent, but manufacturers must consider the non-immunologic issues when using the benzyl alcohol in formulations for cosmetics intended for children and infants.

In addition, Benzyl Alcohol is considered safe for up to 10% as a hair colorant. The small amount of exposure to the body as well as the duration of usage as well as the frequency of use are taken into consideration when determining that nonimmunologic reactions will not pose of concern.

Due to the broad range of products in which benzyl-alcohol can be employed, it is probable that inhalation could be an exposure route. The safety tests available aren’t sufficient to prove the security of benzyl ethanol in formulations in which inhalation is an exposure route. Inhalation toxicology data are required to conclude the safety evaluation of benzyl alcohol in areas where the possibility of inhalation could occur.

4-Hydroxybenzyl alcohol is a polyphenol that is found throughout the world in different kinds of plants. Anti-inflammatory, anti-oxidant, and anti-nociceptive function. Neuroprotective effect. An inhibitor of tumor angiogenesis and growth.

4Hydroxybenzyl Alcohol (HBA) one of the most active ingredients of Gastrodia Elata, has obvious effects on the central nervous system of humans. To obtain compounds that have superior bioactivity, the 10 different derivatives from HBA were made using HBA along with carboxylic acid. The sedative effects of the 10 HBA derivatives were evaluated using a spontaneous locomotor activity test (SLT) in mice, and their hypnotic effects were determined to be synergistic with pentobarbital-induced sleep.

The results showed that 4-hydroxy benzyl alcohol 3-furan carboxylic acid diester (2FHBA, 10 mg kg-1) exhibited the strongest sedative-hypnotic activity among HBA and its derivatives, and 2FHBA could reverse insomnia caused by p-chlorophenyl alanine (pCPA), flumazenil (FLU), and thiosemicarbazide (TSC). Additionally, 2FHBA and 5-hydroxytryptophan (5-HTP) had a synergistic impact. These results suggest that 2FHBA could be a possible drug to treat insomnia. This may be mediated by serotonergic or GABAergic systems.

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Product Specification

  • Appearance & Physical State – white powder
  • Molecular weight – 124.13700
  • Boiling point – 251-253ºC
  • Flash Point – 145.8ºC
  • Density – 1.22 g/cm3
  • Vapor Pressure – 0.010400 mm/Hg @ 25.00 °C
  • Storage Condition – 2-8ºC

Safety Information As Per GHS

Hazard Statement(s) as per GHS

  • H319: Causes serious eye irritation